Topics

1. Forms of Coenzyme Q10

Coenzyme Q10 exists in two forms, ubiquinone and ubiquinol. Both are directly absorbed in the body and play a key role in mitochondrial energy metabolism.
Ubiquinol has advantages in maintaining redox balance and may become the leading form in future market expansion.

Reduced form (Ubiquinol)

• Its launch was delayed by more than 10 years compared to ubiquinone because it is easily oxidized and difficult to manufacture and handle.
• Plays a critical role in the mitochondrial electron transport chain, particularly in the Q-cycle essential for ATP production.
  

Oxidized form (Ubiquinone)

• First introduced as a pharmaceutical, later forming a large supplement market.
• Previously misunderstood to be converted into ubiquinol before absorption in the small intestine; it is now confirmed that it is absorbed in its ingested form.

2. Challenges in Absorption and Formulation

Both ubiquinone and ubiquinol are fat-soluble and insoluble in water. They are generally marketed in soft capsules, but their absorption rate is low.

With the advancement of water-solubilization technologies, absorption has been improved, enabling applications in beverages and new product formats.

3. U.S. Market Trends

• 2024: USD 350 million
• 2025: USD 785.9 million
• 2035: USD 2.13 billion (CAGR 10.5%)

Steady growth is expected, with expanding demand in the healthcare sector.

4. Potential of ShiroQ

CoQ10 exists in two forms, ubiquinone and ubiquinol, both directly absorbed and involved in mitochondrial energy metabolism. Ubiquinol holds advantages in maintaining redox balance and could lead future market growth. With water-solubilization technologies improving bioavailability and expanding applications, ShiroQ represents a promising brand/technology with strong growth potential.